Projects per year
Personal profile
Research interests
Clinical Research:
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Projects:
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Pathophysiology of inherited and acquired cardiac arrhythmias, e.g., Brugada syndrome, Long QT syndrome, drug-induced arrhythmias
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Genetic basis and clinical determinants of inherited heart disease, in particular, primary arrhythmia syndromes, sudden cardiac death, and cardiomyopathies
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Electrophysiological and structural remodeling in right ventricular failure
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Genetic basis of congenital structural heart disease
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Methods:
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Noninvasive cardiac electrophysiology: body surface mapping
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Invasive cardiac electrophysiology: electrophysiologic study, epicardial mapping during cardiac surgery
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Imaging: echocardiography
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Basic Research:
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Projects:
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Molecular basis of right ventricular failure
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Ion channel remodeling in congestive heart failure
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Biophysical characterization of variant ion channels in primary arrhythmia syndromes
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Development of a bio-engineered cardiac pacemaker
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Methods:
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Patch-clamp studies of isolated myocytes and transfected cell cultures
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Electrical and optical activation mapping
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Viral transduction of cultured myocytes
- Imaging: echocardiography
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Specialisation
Cardiology, Cardiogenetics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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CONDUCTION-GTx: Normalising Ventricular Conduction in Heart Failure by Gene Therapies (CONDUCTION-GTx)
Tan, H. (Principal investigator) & Boink, G. (Project Leader)
01/06/2025 → 31/05/2028
Project: Research
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TTW HARVEY: Heart vector-mediated gene therapy: towards a clinically applicable cure for inherited cardiomyopathies
Tan, H. (Principal investigator) & Boink, G. (Project Leader)
TTW: Toegepaste en Technische Wetenschappen
01/01/2021 → 31/12/2025
Project: Research
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EC PROFID (Tan, H.L.): Implementation of personalised risk prediction and prevention of sudden cardiac death after myocardial infarction
Tan, H. (Principal investigator) & Blom, M. (Project Member)
01/01/2020 → 31/03/2026
Project: Research
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Sudden cardiac arrest 4: Sudden cardiac arrest prediction and resuscitation network: Improving the quality of care
Tan, H. (Principal investigator)
01/11/2023 → 25/10/2024
Project: Research
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Sudden cardiac arrest 3: Sudden cardiac arrest prediction and resuscitation network: Improving the quality of care
Tan, H. (Principal investigator)
01/11/2022 → 31/10/2023
Project: Research
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Association Between Delay to First Shock and Successful First-Shock Ventricular Fibrillation Termination in Patients With Witnessed Out-of-Hospital Cardiac Arrest
Stieglis, R., Verkaik, B. J., Tan, H. L., Koster, R. W., van Schuppen, H. & van der Werf, C., 21 Jan 2025, In: Circulation. 151, 3, p. 235-244 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Associations of Clinical Characteristics With Sudden Cardiac Arrest in People With Type 2 Diabetes With and Without Cardiovascular Disease: A Longitudinal Case-Control Study Using Routine Primary Care Data
RESCUED Investigators, 1 Jan 2025, In: Diabetes care. 48, 1, p. 125-135 11 p., 2025;48(1):1–11.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Baseline and 10-year change in the number of ideal cardiovascular health metrics and sudden cardiac death in the community
Empana, J.-P., Perier, M.-C., Warming, P. E., Marijon, E., van Valkengoed, I., Ågesen, F. N., Prescott, E., Jabbari, R., Climie, R. E., Elders, P., Blom, M. T., Schwartz, P. J., Tan, H. L., Tfelt-Hansen, J. & Jouven, X., 1 Apr 2025, In: EP Europace. 27, 4, euaf046.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Defining the terminology of first responders alerted for out-of-hospital cardiac arrest by medical dispatch centres: An international consensus study on nomenclature
Metelmann, C., Metelmann, B., Müller, M. P., Scquizzato, T., Baldi, E., Barry, T., Böttiger, B. W., Busch, H.-J. R., Caputo, M. L., Cheskes, S., Cresta, R., Deakin, C. D., Degraeuwe, E., Doshi, A. A., Ekkel, M. M., Elschenbroich, D., Fredman, D., Gamberini, L., Ganter, J. & Henriksen, F. L. & 25 others, , 1 Mar 2025, In: Resuscitation plus. 22, 100912.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Healthcare professionals’ perspectives on artificial intelligence in patient care: a systematic review of hindering and facilitating factors on different levels
Henzler, D., Schmidt, S., Koçar, A., Herdegen, S., Lindinger, G. L., Maris, M. T., Bak, M. A. R., Willems, D. L., Tan, H. L., Lauerer, M., Nagel, E., Hindricks, G., Dagres, N. & Konopka, M. J., 1 Dec 2025, In: BMC health services research. 25, 1, 633.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access