Personal profile
Research interests
In our lab, we study a diverse range of topics, pertaining to B cell biology, the role of DNA Damage Repair (DDR) systems in lymphomagenesis and Multiple Myeloma. My project specifically focuses on translational research in Multiple Myeloma. Our goal is to unravel key metabolic processes in Myeloma with the eventual aim to exploit the metabolic vulnerabilities in these cells for therapeutic benefit.
Specialisation
B-cell neoplasms, Multiple Myeloma.
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Collaborations and top research areas from the last five years
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AKT supports the metabolic fitness of multiple myeloma cells by restricting FOXO activity
Bloedjes, T. A., de Wilde, G., Khan, G. H., Ashby, T. C., Shaughnessy, J. D., Zhan, F., Houtkooper, R. H., Bende, R. J., van Noesel, C. J. M., Spaargaren, M. & Guikema, J. E. J., 9 May 2023, In: Blood advances. 7, 9, p. 1697-1712 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile22 Downloads (Pure) -
Metabolic effects of recurrent genetic aberrations in multiple myeloma
Bloedjes, T. A., de Wilde, G. & Guikema, J. E. J., 1 Feb 2021, In: Cancers. 13, 3, p. 1-36 36 p., 396.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile22 Downloads (Pure) -
AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma
Bloedjes, T. A., de Wilde, G., Maas, C., Eldering, E., Bende, R. J., van Noesel, C. J. M., Pals, S. T., Spaargaren, M. & Guikema, J. E. J., 8 Sept 2020, In: Blood advances. 4, 17, p. 4151-4164Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile25 Downloads (Pure) -
The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors
Bahjat, M., de Wilde, G., van Dam, T., Maas, C., Bloedjes, T., Bende, R. J., van Noesel, C. J. M., Luijks, D. M., Eldering, E., Kersten, M. J. & Guikema, J. E. J., Sept 2019, In: Cell cycle (Georgetown, Tex.). 18, 18, p. 2307-2322 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile26 Downloads (Pure)