Research output per year
Research output per year
Personal profile
Research interests
In my research group we investigate the critical processes of placental development during pregnancy. This includes studying human model systems such as trophoblast stem cells, cell lines, organoids, and placental explants to understand normal development in the first trimester and conditions leading to placental dysfunction, such as pre-eclampsia and fetal growth restriction.
The use of trophoblast stem cells and organoids offers powerful tools for advancing our understanding of placental biology and pregnancy complications, potentially leading to new diagnostic and therapeutic strategies.
Specialisation
Placenta, Molecular Biology, Pregnancy Complications, Stem Cells, Organoids
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Generation of Bona Fide Human Induced Trophoblast Stem Cells by Direct Reprogramming of Term Umbilical Cord Cells
van Voorden, A. J., Boussata, S., Keijser, R., Vermij, M., Wagner, M. K., Ganzevoort, W. & Afink, G. B., 1 Jan 2025, In: International journal of molecular sciences. 26, 1, 271.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile12 Downloads (Pure) -
Corrigendum to “COVID-19 mRNA vaccination during pregnancy does not harm syncytiotrophoblast development” [International Journal of Infectious Diseases, 140C (2024) pages 95-98, (S1201971224000158), (10.1016/j.ijid.2024.01.014)]
van Voorden, J., de Groot, C. J. M., Ris-Stalpers, C., Afink, G. B. & van Leeuwen, E., 1 Jul 2024, In: International Journal of Infectious Diseases. 144, 107068.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open AccessFile3 Downloads (Pure) -
COVID-19 mRNA vaccination during pregnancy does not harm syncytiotrophoblast development
van Voorden, J., de Groot, C. J. M., Ris-Stalpers, C., Afink, G. B. & van Leeuwen, E., Mar 2024, In: International journal of infectious diseases : IJID. 140, p. 95-98 4 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Downloads (Pure) -
EP300 facilitates human trophoblast stem cell differentiation
van Voorden, A. J., Keijser, R., Veenboer, G. J. M., Lopes Cardozo, S. A., Diek, D., Vlaardingerbroek, J. A., van Dijk, M., Ris-Stalpers, C., van Pelt, A. M. M. & Afink, G. B., 11 Jul 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 28, p. e2217405120 e2217405120.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Downloads (Pure) -
Tricky TRIC: A replication study using trophoblast retrieval and isolation from the cervix to study genetic birth defects
van Dijk, M., Boussata, S., Janssen, D., Afink, G., Jebbink, J., van Maarle, M., Wortelboer, E., Kooper, A. & Pajkrt, E., 1 Dec 2022, In: Prenatal diagnosis. 42, 13, p. 1612-1621 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Downloads (Pure)
Activities
- 1 Invited talk
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The ins-and-outs of human trophoblast stem cells
Afink, G. (Speaker)
3 Jul 2022Activity: Talk or presentation › Invited talk › Academic
Datasets
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Additional file 4: of The idiopathic preterm delivery methylation profile in umbilical cord blood DNA
Fernando, F. (Contributor), Keijser, R. (Creator), Henneman, P. (Creator), van der Kevie-Kersemaekers, A.-M. F. (Contributor), Mannens, M. M. A. M. (Creator), van der Post, J. A. M. (Contributor), Afink, G. B. (Creator) & Ris-Stalpers, C. (Creator), Figshare, 2015
DOI: 10.6084/m9.figshare.c.3622160_d3.v1, https://springernature.figshare.com/articles/dataset/Additional_file_4_of_The_idiopathic_preterm_delivery_methylation_profile_in_umbilical_cord_blood_DNA/4397096/1
Dataset
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Additional file 1: of The idiopathic preterm delivery methylation profile in umbilical cord blood DNA
Fernando, F. (Contributor), Keijser, R. (Creator), Henneman, P. (Creator), van der Kevie-Kersemaekers, A.-M. F. (Contributor), Mannens, M. M. A. M. (Creator), van der Post, J. A. M. (Contributor), Afink, G. B. (Creator) & Ris-Stalpers, C. (Creator), Figshare, 2015
DOI: 10.6084/m9.figshare.c.3622160_d5.v1, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_The_idiopathic_preterm_delivery_methylation_profile_in_umbilical_cord_blood_DNA/4397123/1
Dataset
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Additional file 6: of The idiopathic preterm delivery methylation profile in umbilical cord blood DNA
Fernando, F. (Contributor), Keijser, R. (Creator), Henneman, P. (Creator), van der Kevie-Kersemaekers, A.-M. F. (Contributor), Mannens, M. M. A. M. (Creator), van der Post, J. A. M. (Contributor), Afink, G. B. (Creator) & Ris-Stalpers, C. (Creator), Figshare, 2015
DOI: 10.6084/m9.figshare.c.3622160_d4.v1, https://springernature.figshare.com/articles/dataset/Additional_file_6_of_The_idiopathic_preterm_delivery_methylation_profile_in_umbilical_cord_blood_DNA/4397114/1
Dataset
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Additional file 3: of The idiopathic preterm delivery methylation profile in umbilical cord blood DNA
Fernando, F. (Contributor), Keijser, R. (Creator), Henneman, P. (Creator), van der Kevie-Kersemaekers, A.-M. F. (Contributor), Mannens, M. M. A. M. (Creator), van der Post, J. A. M. (Contributor), Afink, G. B. (Creator) & Ris-Stalpers, C. (Creator), Figshare, 2015
DOI: 10.6084/m9.figshare.c.3622160_d2.v1, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_The_idiopathic_preterm_delivery_methylation_profile_in_umbilical_cord_blood_DNA/4397087/1
Dataset
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Additional file 3: of The idiopathic preterm delivery methylation profile in umbilical cord blood DNA
Fernando, F. (Contributor), Keijser, R. (Creator), Henneman, P. (Creator), van der Kevie-Kersemaekers, A.-M. F. (Contributor), Mannens, M. M. A. M. (Creator), van der Post, J. A. M. (Contributor), Afink, G. B. (Creator) & Ris-Stalpers, C. (Creator), Figshare, 2015
DOI: 10.6084/m9.figshare.c.3622160_d2, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_The_idiopathic_preterm_delivery_methylation_profile_in_umbilical_cord_blood_DNA/4397087
Dataset