Personal profile
Research interests
My research is aimed to understand the molecular mechanisms that contribute to hematopoietic stem cell (HSC) functioning.
A small population of selfrenewing HSCs ensures that all the various types of blood cells are produced during the lifetime of an organism. Nevertheless, during aging blood cell production is impaired, resulting in either a deficit of blood cells (leading to anemia, thromocytopenia, or susceptibility to infections) or an excess of blood cells (myeloproliferative diseases or leukemias).
The identification of the molecular machinery that is associated with aberrant selfrenewal of aged HSCs should allow the development of interventions that improve or restore selfrenewal of normal aged stem cells, and that target exessive selfrenewal of leukemic stem cells.
Specialisation
Hematology, Stem cells, Aging, Leukemia
Education/Academic qualification
Bijzonder hoogleraar met de leeropdracht Moleculaire Stamcelbiologie, University of Amsterdam
1 Mar 2022 → …
External positions
Directeur research Sanquin, Sanquin
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
-
SDG 3 Good Health and Well-being
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Aberrant engagement of P-selectin drives hematopoietic stem cell aging in mice
Yang, D., Skinder, N., Kao, Y.-R., Chen, J., Thiruthuvanathan, V., Flohr Svendsen, A., Zhang, C., Dethmers-Ausema, B., Weersing, E., Maryanovich, M., Will, B. & de Haan, G., Jun 2025, In: Nature Aging. 5, 6, p. 1010-1024 15 p., 2665.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile33 Downloads (Pure) -
CBX7 inhibitors affect H3K9 methyltransferase-regulated gene repression in leukemic cells
de Groot, A. P., Nguyen, H., Pouw, J. S., Weersing, E., Dethmers-Ausema, A. & de Haan, G., 1 Feb 2025, In: Experimental hematology. 142, 104691.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile34 Downloads (Pure) -
CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal
Skinder, N., Fernández, I. S., Dethmers-Ausema, A., Weersing, E. & Haan, G. D., 9 Jan 2024, In: Blood advances. 8, 1, p. 99-111 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile18 Downloads (Pure) -
How CBX proteins regulate normal and leukemic blood cells
de Groot, A. P. & de Haan, G., Nov 2024, In: FEBS letters. 598, 22, p. 2788-2806 19 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile38 Downloads (Pure) -
Pharmacological targeting of CBX7 alters the epigenetic landscape and induces differentiation of leukemic cells
de Groot, A. P., Wilson, C. R., Weersing, E., Pouw, J. S., Dethmers-Ausema, A., Nguyen, H., Chen, E. F. W., Shaurya, A., Smit, L., Hof, F. & de Haan, G., 1 Dec 2024, In: Blood Neoplasia. 1, 4, 100052.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile18 Downloads (Pure)