Projects per year
Personal profile
Research interests
My research is aimed to understand the molecular mechanisms that contribute to hematopoietic stem cell (HSC) functioning.
A small population of selfrenewing HSCs ensures that all the various types of blood cells are produced during the lifetime of an organism. Nevertheless, during aging blood cell production is impaired, resulting in either a deficit of blood cells (leading to anemia, thromocytopenia, or susceptibility to infections) or an excess of blood cells (myeloproliferative diseases or leukemias).
The identification of the molecular machinery that is associated with aberrant selfrenewal of aged HSCs should allow the development of interventions that improve or restore selfrenewal of normal aged stem cells, and that target exessive selfrenewal of leukemic stem cells.
Specialisation
Hematology, Stem cells, Aging, Leukemia
Education/Academic qualification
Bijzonder hoogleraar met de leeropdracht Moleculaire Stamcelbiologie, University of Amsterdam, Netherlands
1 Mar 2022 → …
External positions
Directeur research Sanquin, Sanquin
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Reprogramming hematopoietic progenitors to generate transplantable stem cells
de Haan, G. (Principal investigator)
01/06/2016 → …
Project: Research
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Juvenile sablefish condition and growth
de Haan, G. (Principal investigator), Kato, S. S. (Principal investigator), Sakai, Y. Y. (CoPI), Thongkao, S. S. (CoPI), Chantrapromma, K. K. (CoPI), Boonming, S. S. (CoPI), Beaudreau, A. A. (Principal investigator) & Heintz, R. R. (CoPI)
Landsteiner Foundation for Blood Transfusion Research
15/09/2016 → 31/12/2020
Project: Research
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Early Stage Investors and Entrepreneurs in Emerging Markets
Van Os, R. R. (Principal investigator), de Haan, G. (CoPI) & Colonnelli, E. E. (Principal investigator)
Landsteiner Foundation for Blood Transfusion Research
01/01/2007 → 30/11/2023
Project: Research
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EXPANSION OF STEM CELLS BY FIBROBLAST GROWTH FACTOR-1
de Haan, G. (Principal investigator)
National Heart, Lung, and Blood Institute
15/08/2003 → 31/07/2004
Project: Research
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CBX7 inhibitors affect H3K9 methyltransferase-regulated gene repression in leukemic cells
de Groot, A. P., Nguyen, H., Pouw, J. S., Weersing, E., Dethmers-Ausema, A. & de Haan, G., 1 Feb 2025, In: Experimental hematology. 142, 104691.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal
Skinder, N., Fernández, I. S., Dethmers-Ausema, A., Weersing, E. & Haan, G. D., 9 Jan 2024, In: Blood advances. 8, 1, p. 99-111 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
How CBX proteins regulate normal and leukemic blood cells
de Groot, A. P. & de Haan, G., Nov 2024, In: FEBS letters. 598, 22, p. 2788-2806 19 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access1 Citation (Scopus) -
Polychromatic Flow Cytometry to Identify Rare Aged Hematopoietic Stem Cell Subpopulations
Skinder, N., Pitsillidou, C., Roberto, A. & de Haan, G., 25 Sept 2024, (E-pub ahead of print) In: Methods in molecular biology (Clifton, N.J.).Research output: Contribution to journal › Article › Academic › peer-review
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3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice
Guerrero, A., Innes, A. J., Roux, P.-F., Buisman, S. C., Jung, J., Ortet, L., Moiseeva, V., Wagner, V., Robinson, L., Ausema, A., Potapova, A., Perdiguero, E., Weersing, E., Aarts, M., Martin, N., Wuestefeld, T., Muñoz-Cánoves, P., de Haan, G., Bischof, O. & Gil, J., Sept 2022, In: Nature Aging. 2, 9, p. 851-866 16 p.Research output: Contribution to journal › Article › Academic › peer-review
7 Citations (Scopus)