The focus of my group’s work is on the metabolism of complex lipids and their role in genetic disease, acquired disorders and ageing. We combine detailed knowledge of human metabolism from a clinical/translational perspective with the world-renowned technical know-how of metabolomics to perform research on metabolism. By characterizing metabolism using state-of-the-art analytical techniques in combination with, in house, tailor-made bioinformatics we have created a set of metabolomics platforms including targeted assays, small molecule metabolomics, fluxomics and lipidomics which we successfully apply to characterize the metabolome in different (disease) model systems ranging from bacteria to human tissues. Our ultimate goal is to use these technologies to unravel pathologic mechanism of disease and promote the development of new therapeutic strategies for both inherited and acquired disorders.

Clinical Biochemist inborn errors of metabolism

BKO certified instructor