Floriaan Schmidt

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Floriaan Schmidt

Principal Investigator

 https://orcid.org/0000-0003-1327-0424
20132025

Research activity per year

Personal profile

Research interests

A. Floriaan Schmidt has received training in public health, clinical epidemiology, and mathematics. Floriaan completed a PhD on methods for personalized medicine with the Utrecht University in the Netherlands. Following his PhD, he accepted a position with University College London (UCL). Currently, Floriaan has a joined position with Amsterdam UMC and UCL. His research focusses on developing and applying human genetics for drug target validation (Schmidt, Nature Communications 2020 & 2021). Additionally, Floriaan conducts research to improve risk prediction modelling by integrating electronic healthcare records data with information from multi-modal sources, including imaging, genomics and metabolomics. Floriaan has received funding from the British Heart Foundation, the National Institute for Health Research University College London Hospitals Biomedical Research Centre, Servier, New Amsterdam Pharma, Health Data Research UK, IMI, Erasmus+, ERC horizon, ERC/UKRI Consolidator.

Specialisation

Epidemiology

Statistical learning

Machine learning 

Prediction research

Causal inference

Mendelian randomization

Human genetics

 

Education/Academic qualification

Bachelor, Mathematics and Statistics, Open University

Award Date: 1 Jul 2022

PhD, Epidemiology, Universiteit Utrecht: UMC Utrecht

Award Date: 24 Jun 2014

Master, Clinical Epidemiology, Utrecht University

Award Date: 1 Jun 2012

Master, Public health and infectious disease, VU University Amsterdam

Award Date: 1 Aug 2010

External positions

University College London

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  • Cardiovascular risk prediction in type 2 diabetes: a comparison of 22 risk scores in primary care settings

    Dziopa, K., Asselbergs, F. W., Gratton, J., Chaturvedi, N. & Schmidt, A. F., 1 Apr 2022, In: Diabetologia. 65, 4, p. 644-656 13 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    56 Citations (Scopus)

  • Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity

    Schmidt, A. F., Bourfiss, M., Alasiri, A., Puyol-Anton, E., Chopade, S., van Vugt, M., van der Laan, S. W., Gross, C., Clarkson, C., Henry, A., Lumbers, T. R., van der Harst, P., Franceschini, N., Bis, J. C., Velthuis, B. K., te Riele, A. S. J. M., Hingorani, A. D., Ruijsink, B., Asselbergs, F. W. & van Setten, J. & 1 others, Finan, C., 28 Apr 2023, In: Science advances. 9, 17, p. eadd4984 eadd4984.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    16 Citations (Scopus)

  • Genetic drug target validation using Mendelian randomisation

    Schmidt, A. F., Finan, C., Gordillo-Marañón, M., Asselbergs, F. W., Freitag, D. F., Patel, R. S., Tyl, B., Chopade, S., Faraway, R., Zwierzyna, M. & Hingorani, A. D., 1 Dec 2020, In: Nature communications. 11, 1, 3255.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    280 Citations (Scopus)

  • Joint Genetic Inhibition of PCSK9 and CETP and the Association With Coronary Artery Disease: A Factorial Mendelian Randomization Study

    Cupido, A. J., Reeskamp, L. F., Hingorani, A. D., Finan, C., Asselbergs, F. W., Hovingh, G. K. & Schmidt, A. F., 1 Sept 2022, In: JAMA cardiology. 7, 9, p. 955-964 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    42 Citations (Scopus)

  • PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study: a mendelian randomisation study

    Schmidt, A. F., Swerdlow, D. I., Holmes, M. V., Patel, R. S., Fairhurst-Hunter, Z., Lyall, D. M., Hartwig, F. P., Horta, B. L., Hyppönen, E., Power, C., Moldovan, M., van Iperen, E., Hovingh, G. K., Demuth, I., Norman, K., Steinhagen-Thiessen, E., Demuth, J., Bertram, L., Liu, T. & Coassin, S. & 113 others, Willeit, J., Kiechl, S., Willeit, K., Mason, D., Wright, J., Morris, R., Wanamethee, G., Whincup, P., Ben-Shlomo, Y., McLachlan, S., Price, J. F., Kivimaki, M., Welch, C., Sanchez-Galvez, A., Marques-Vidal, P., Nicolaides, A., Panayiotou, A. G., Onland-Moret, N. C., van der Schouw, Y. T., Matullo, G., Fiorito, G., Guarrera, S., Sacerdote, C., Wareham, N. J., Langenberg, C., Scott, R., Luan, J., Bobak, M., Malyutina, S., Pająk, A., Kubinova, R., Tamosiunas, A., Pikhart, H., Husemoen, L. L. N., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Simonsen, K. S., Cooper, J., Humphries, S. E., Brilliant, M., Kitchner, T., Hakonarson, H., Carrell, D. S., McCarty, C. A., Kirchner, H. L., Larson, E. B., Crosslin, D. R., de Andrade, M., Roden, D. M., Denny, J. C., Carty, C., Hancock, S., Attia, J., Holliday, E., O'Donnell, M., Yusuf, S., Chong, M., Pare, G., van der Harst, P., Said, M. A., Eppinga, R. N., Verweij, N., Snieder, H., Christen, T., Mook-Kanamori, D. O., Gustafsson, S., Lind, L., Ingelsson, E., Pazoki, R., Franco, O., Hofman, A., Uitterlinden, A., Dehghan, A., Teumer, A., Baumeister, S., Dörr, M., Lerch, M. M., Völker, U., Völzke, H., Ward, J., Pell, J. P., Smith, D. J., Meade, T., Maitland-van der Zee, A. H., Baranova, E. V., Young, R., Ford, I., Campbell, A., Padmanabhan, S., Bots, M. L., Grobbee, D. E., Froguel, P., Thuillier, D., Balkau, B., Bonnefond, A., Cariou, B., Smart, M., Bao, Y., Kumari, M., Mahajan, A., Ridker, P. M., Chasman, D. I., Reiner, A. P., Lange, L. A., Ritchie, M. D., Asselbergs, F. W., Casas, J.-P., Keating, B. J., Preiss, D., Hingorani, A. D. & Sattar, N., Feb 2017, In: Lancet. Diabetes and endocrinology. 5, 2, p. 97-105 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    309 Citations (Scopus)
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