Personal profile
Research interests
My research focuses on the development of advanced molecular therapies for rare (neurometabolic) diseases, with a particular emphasis on in vivo gene editing. In addition to technological innovation, I address implementation challenges to improve the availability, accessibility, and affordability of innovative therapies, enabling timely clinical translation and patient access.
Specialisation
Assistant Professor Molecular Therapy Development | Emma Center for Personalized Medicine | Department of Human Genetics | Amsterdam UMC
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Collaborations and top research areas from the last five years
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PHF6 promotes non-homologous end joining and G2 checkpoint recovery
Warmerdam, D. O., Alonso-de Vega, I., Wiegant, W. W., van den Broek, B., Rother, M. B., Wolthuis, R. M. F., Freire, R., van Attikum, H., Medema, R. H. & Smits, V. A. J., 7 Jan 2020, In: EMBO reports. 21, 1, e48460.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile16 Downloads (Pure) -
Apc-mutant cells act as supercompetitors in intestinal tumour initiation
van Neerven, S. M., de Groot, N. E., Nijman, L. E., Scicluna, B. P., van Driel, M. S., Lecca, M. C., Warmerdam, D. O., Kakkar, V., Moreno, L. F., Vieira Braga, F. A., Sanches, D. R., Ramesh, P., ten Hoorn, S., Aelvoet, A. S., van Boxel, M. F., Koens, L., Krawczyk, P. M., Koster, J., Dekker, E. & Medema, J. P. & 5 others, , 17 Jun 2021, In: Nature. 594, 7863, p. 436-441 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile60 Downloads (Pure) -
Keeping ribosomal DNA intact: a repeating challenge
Warmerdam, D. O. & Wolthuis, R. M. F., 15 Mar 2019, In: Chromosome research. 27, 1-2, p. 57-72Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile18 Downloads (Pure) -
Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats
Warmerdam, D. O., van den Berg, J. & Medema, R. H., 22 Mar 2016, In: Cell reports. 14, 11, p. 2519-2527 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Reassessing human MHC-I genetic diversity in T cell studies
Slieker, R. C., Warmerdam, D. O., Vermeer, M. H., van Doorn, R., Heemskerk, M. H. M. & Scheeren, F. A., Dec 2024, In: Scientific reports. 14, 1, p. 7966 1 p., 7966.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile49 Downloads (Pure)