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Cristina Pina

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Cristina Pina

DR., Principal Investigator

 https://orcid.org/0000-0002-2575-6301
  • 2308
    Citations
20052025

Research activity per year

Personal profile

Research interests

I am a medically-trained scientist researching regulation of cell identity. I focus on the haematopoietic system, specifically the role of transcriptional noise and epigenetic factors in haematopoietic stem cell biology and leukaemia evolution.

Specialisation

Haematopoiesis: haematopoietic stem cells, leukaemia. 3D models of blood development. Transcriptional and epigenetic regulation. Transcriptional noise.

Related documents

Education/Academic qualification

Master, Fellowship of the Higher Education Academy United Kingdom, Brunel University London

1 Oct 2019 → 6 Jul 2020

Award Date: 6 Jul 2020

PhD, Transcriptional Programming in Cord Blood-Derived Haematopoietic Stem Cells , University of Oxford

6 Oct 2003 → 23 Jul 2008

Award Date: 23 Jul 2008

Master, Medicine (6-year degree, basic and clinical cycle), Medical School of University of Lisbon, Lisbon, Portugal

1 Oct 1992 → 15 Jul 1998

Award Date: 15 Jul 1998

External positions

Principal investigator, Sanquin Blood Supply Foundation

1 May 2025 → …

Divisional Research Lead for Biomedical Sciences, Brunel University London

1 Jan 2023 → 30 Apr 2025

Senior Lecturer in Biomedical Sciences, Brunel University London

9 Sept 2019 → 30 Apr 2025

Senior Research Associate and Research Group Leader - Department of Genetics, University of Cambridge

1 Feb 2019 → 8 Sept 2019

Senior Research Associate and Principal Investigator - Department of Haematology, University of Cambridge

1 Dec 2015 → 31 Jan 2019

Research Associate - Department of Haematology, University of Cambridge

1 Jul 2013 → 30 Nov 2015

Research Associate - Cancer Institute, University College London

1 Apr 2011 → 30 Jun 2013

Post Doctoral Research Fellow, MRC Molecular Haematology Unit, University of Oxford

1 May 2008 → 31 Mar 2011

Specialist Registrar - Internal Medicine, Santa Maria University Hospital, Lisbon

1 Jan 2001 → 31 Aug 2002

Medical Doctor - Internal Medicine, Santa Maria University Hospital

1 Aug 2000 → 31 Dec 2000

Pre-registration Intern Medical Doctor, Santa Maria University Hospital

1 Jan 1999 → 31 Jul 2000

Guest Lecturer in Histology and Embryology, Medical School of University of Lisbon, Lisbon, Portugal

1 Oct 1997 → 31 Aug 2002

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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Collaborations and top research areas from the last five years

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  • Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

    Ragusa, D., Suen, C.-W., Torregrosa-Cortes, G., Pastorino, F., Johns, A., Ciciro, Y., Dijkhuis, L., van den Brink, S., Cilli, M., Byrne, C., Ionescu, G.-A., Cerveira, J., Kranc, K. R., Hernandez-Hernandez, V., Ponzoni, M., Bigas, A., Garcia-Ojalvo, J., Martinez-Arias, A. & Pina, C., 12 Sept 2025, In: eLife.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    24 Downloads (Pure)

  • Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles

    Ragusa, D., Cicirò, Y., Federico, C., Saccone, S., Bruno, F., Saeedi, R., Sisu, C., Pina, C., Sala, A. & Tosi, S., 1 Dec 2022, In: Oncogenesis. 11, 1, 50.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    23 Downloads (Pure)

  • Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis

    Gupta, S., Dovey, O. M., Domingues, A. F., Cyran, O. W., Cash, C. M., Giotopoulos, G., Rak, J., Cooper, J., Gozdecka, M., Dijkhuis, L., Asby, R. J., Al-Jabery, N., Hernandez-Hernandez, V., Prabakaran, S., Huntly, B. J., Vassiliou, G. S. & Pina, C., 5 Aug 2022, In: Science advances. 8, 31, eabn4886.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    13 Downloads (Pure)

  • KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia

    Arede, L., Foerner, E., Wind, S., Kulkarni, R., Domingues, A. F., Giotopoulos, G., Kleinwaechter, S., Mollenhauer-Starkl, M., Davison, H., Chandru, A., Asby, R., Samarista, R., Gupta, S., Forte, D., Curti, A., Scheer, E., Huntly, B. J. P., Tora, L. & Pina, C., 11 Jan 2022, In: Blood. 6, 1, p. 165-180

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    14 Downloads (Pure)

  • Loss of KAT2A enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells

    Domingues, A. F., Kulkarni, R., Giotopoulos, G., Gupta, S., Vinnenberg, L., Arede, L., Foerner, E., Khalili, M., Adao, R. R., Johns, A., Tan, S., Zeka, K., Huntly, B. J., Prabakaran, S. & Pina, C., 1 Jan 2020, In: eLife. 9, e51754.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    20 Downloads (Pure)
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