Personal profile
Research interests
We study the gut-liver axis in the pathogenesis of liver diseases, including NAFLD/NASH (MAFLD/MASH) and cholestasis. We aim to identify gut-derived factors and intestinal/hepatic signaling pathways involved in the pathogenesis of aforementioned diseases.
Specialisation
Lipid and glucose Metabolism, transport processes in the liver, cholestasis, NAFLD, NASH
Education/Academic qualification
PhD, The molecular basis of conjugated hyperbilirubinemia, Amsterdam UMC
1 Apr 1994 → 1 Oct 1998
Award Date: 1 Oct 1998
Keywords
- Q Science (General)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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ATP8B1 Deficiency Causes Phosphodiesterase 4-Mediated Glucagon Resistance and Impaired Gluconeogenesis in Mouse and Human Liver
Chang, J.-C., Panhuis, W. I. H., Hsu, S.-H., Duijst, S., Ho-Mok, K. S., van der Heiden, J. F., Ying, Z., Erdmann, J. I., Vogel, G. F., Junge, N., Hartleben, B., Koelink, P. J., van Dijk, S. G., Peng, W. C., Verhoeven, A. J., Oude Elferink, R. P. J., Chen, H.-L., van de Graaf, S. F. J. & Paulusma, C. C., 1 Sept 2025, In: Liver international. 45, 9, e70306.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile35 Downloads (Pure) -
NTCP ubiquitination enables HBV infection
Appelman, M. D., Nguyen, T.-A., Oswald, A., Lucko, A., Paulusma, C. C., Protzer, U. & van de Graaf, S. F. J., 1 Nov 2025, In: JHEP Reports. 7, 11, 101534.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile51 Downloads (Pure) -
The role of bile salts in itch receptor activation
Wolters, F., Tolenaars, D., van Weeghel, M., de Waart, D., van de Graaf, S. F. J., Paulusma, C. C., Verhoeven, A., Beuers, U. & Oude Elferink, R., 1 Nov 2025, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1871, 8, 167972.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Downloads (Pure) -
Bile salt signaling and bile salt-based therapies in cardiometabolic disease
Groenen, C. C. J., Nguyen, T.-A., Paulusma, C. C. & van de Graaf, S. F. J., 10 Jan 2024, In: Clinical science (London, England. 138, 1, p. 1-21 21 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile105 Downloads (Pure) -
Getting in the zone: Metabolite transport across liver zones
van de Graaf, S. F. J., Paulusma, C. C. & in het Panhuis, W., 1 Nov 2024, In: Acta Physiologica. 240, 11, e14239.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile57 Downloads (Pure)
Courses
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Professionele ontwikkeling - 2
Nieuwenhuijsen, K., Roossien, L. & van den Berg, J. 02/09/2024 → 23/06/2025
Course