Projects per year
Personal profile
Research interests
- Protease activated receptors and macrophages in pulmonary fibrosis.
- Protease activated receptor 1 in cell fate decesions.
- C/EBPdelta: master regulator of pancreatic cancer progression.
- Mesoporous silica nanoparticles as drug carriers in pancreatic cancer.
specialisation
Molecular Cell Biology
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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Targeted chemotherapy in pancreatic cancer: proof of principle in preclinical models.
Spek, C. (Principal investigator), Kros, A. A. (CoPI) & Bijlsma, M. (CoPI)
01/01/2017 → …
Project: Research
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Identification of C/EBPδ-Modifying Compounds as Potential Anticancer Agents Using a High-Throughput Drug Screen
Hartl, L., Duitman, J., Aberson, H. L., Medema, J. P., Bijlsma, M. F. & Spek, C. A., 1 Feb 2025, In: Journal of cellular and molecular medicine. 29, 3, e70287.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
CAPN2-responsive mesoporous silica nanoparticles: A promising nanocarrier for targeted therapy of pancreatic cancer
Slapak, E. J., el Mandili, M., ten Brink, M. S., Kros, A., Bijlsma, M. F. & Spek, C. A., 28 May 2024, In: Cancer letters. 590, 216845.Research output: Contribution to journal › Article › Academic › peer-review
Open Access4 Citations (Scopus) -
Hypoxia Abrogates Tumor-Suppressive Activities of C/EBPδ in Pancreatic Cancer
Hartl, L., ten Brink, M. S., Aberson, H. L., Koster, J., Zwijnenburg, D. A., Duitman, J., Bijlsma, M. F. & Spek, C. A., 1 Sept 2024, In: International journal of molecular sciences. 25, 17, 9449.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Identification of pancreatic cancer-specific protease substrates for protease-dependent targeted delivery
Slapak, E. J., Zwijnenburg, D. A., Koster, J., Bijlsma, M. F. & Spek, C. A., 1 Dec 2024, In: Oncogenesis. 13, 1, 40.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC
Hartl, L., Roelofs, J. J. T. H., Dijk, F., Bijlsma, M. F., Duitman, J. & Spek, C. A., 1 Jan 2023, In: International journal of molecular sciences. 24, 2, 1537.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus)
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Doctoral committee member Dr Melissa Uil
Spek, C. A. (Examiner)
2022Activity: Examination › Educational
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Cells (Journal)
Spek, C. A. (Member of editorial board)
1 Jan 2021 → …Activity: Publication peer-review and editorial work › Editorial activity
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Biology (Journal)
Spek, C. A. (Member of editorial board)
1 Jan 2020 → …Activity: Publication peer-review and editorial work › Editorial activity