Research output per year
Research output per year
Personal profile
Research interests
Vascular cell biology and diabetes
Macrophages in vascular disease
Nuclear hormone receptors; NR4A-subfamily: Nur77
NR4As in metabolism
LIM domain-only protein FHL2, co-regulator of Nur77, in atherosclerosis, coagulation and obesity.
Expertise: Cell culture of human vascular smooth muscle cells and mouse macrophages, atherosclerosis in dedicated mouse models, lentiviral infection of primary vascular cells, high-fat diet induced diabetes in mice.
Specialisation
Medical Cell Biochemistry
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism
Koenis, D. S., Medzikovic, L., van Loenen, P. B., van Weeghel, M., Huveneers, S., Vos, M., Evers-van Gogh, I. J., van den Bossche, J., Speijer, D., Kim, Y., Wessels, L., Zelcer, N., Zwart, W., Kalkhoven, E. & de Vries, C. J., 21 Aug 2018, In: Cell reports. 24, 8, p. 2127-2140.e7Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1 α and affect bone marrow homeostasis in mice and humans
Koenis, D. S., Medzikovic, L., Vos, M., Beldman, T. J., van Loenen, P. B., van Tiel, C. M., Hamers, A. A. J., Rubio, I. O., de Waard, V. & de Vries, C. J. M., 2018, In: Journal of biological chemistry. 293, 39, p. 15070-15083Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
NR4A nuclear receptors are orphans but not lonesome
Kurakula, K., Koenis, D. S., van Tiel, C. M. & de Vries, C. J. M., Nov 2014, In: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1843, 11, p. 2543-2555 13 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access -
Deficiency of FHL2 attenuates airway inflammation in mice and genetic variation associates with human bronchial hyper-responsiveness
Kurakula, K., Vos, M., Logiantara, A., Roelofs, J. J. T. H., Nieuwenhuis, M. A., Koppelman, G. H., Postma, D. S., Brandsma, C. A., Sin, D. D., Bossé, Y., Nickle, D. C., van Rijt, L. S. & de Vries, C. J. M., 1 Dec 2015, In: Allergy. 70, 12, p. 1531-1544 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile45 Downloads (Pure) -
Bone Marrow-Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis
Hamers, A. A. J., Vos, M., Rassam, F., Marincovic, G., Kurakula, K., van Gorp, P. J., de Winther, M. P. J., Gijbels, M. J. J., de Waard, V. & de Vries, C. J. M., 2012, In: Circulation research. 110, 3, p. 428-U147Research output: Contribution to journal › Article › Academic › peer-review