Personal profile
Research interests
Ylstra received a bachelors in Physics in 1988 from the University of Amsterdam (UvA, NL) and commenced with a masters in Genetics at the Vrije Universiteit (VU, NL). In 1995 he received his PhD degree from the same university for work performed at the Universities of Vienna (A) and Nijmegen (NL), Plant Research International (NL) and The John Innes Institute (UK). He was awarded a 2-year NATO fellowship for his post-doctoral work at the University of California in Berkeley (USA) on genome-wide RNA screens . From 1998 he worked at the Comprehensive Cancer Center of the University of California, San Francisco (USA) and was involved in the development of DNA arrays for copy number analysis. In 2001 he accepted his current position at the VU University Medical Center, Cancer Center Amsterdam heading the Tumor Genome Analysis Core. The core has a strong genome laboratory and bioinformatics (pre-)processing track record, with an emphasis on DNA analysis from archival material, see more under http://www.tgac.nl.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Bridging the gap between tumor evolution and clonality diagnostics in multiple lung carcinomas
Janssen, J., Allgäuer, M., Ylstra, B., Draijer, S., Kim, Y., Budczies, J., Kazdal, D., Stenzinger, A., Kirchner, M. & Radonic, T., May 2026, In: Seminars in cancer biology. 122, p. 1-15 15 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access -
TET CpG sequence-context-specific DNA demethylation shapes progression of IDH-mutant gliomas
Hoogstrate, Y., Ghisai, S. A., van Hijfte, L., Head, R., de Heer, I., Padovan, M., de Wit, M., Vallentgoed, W. R., Dipasquale, A., Wijnenga, M. M. J., Weenink, B., Luning, R., Maas, S. L. N., Brzobohata, A., Weller, M., Weiss, T., Mair, M. J., Berghoff, A. S., Wöhrer, A. & Jeltsch, A. & 14 others, , 17 Mar 2026, In: Cell Reports Medicine. 7, 3, 102682.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Advancing Lung Cancer Staging: Integrating IASLC Recommendations and Bioinformatics to Delineate Tumor Origins
Allgäuer, M., Kluck, K., Christopoulos, P., Ball, M., Volckmar, A.-L., Radonic, T., Bubendorf, L., Hofman, P., Heußel, C. P., Winter, H., Herth, F., Thomas, M., Ylstra, B., Peters, S., Schirmacher, P., Kazdal, D., Budczies, J., Stenzinger, A. & Kirchner, M., 2025, (E-pub ahead of print) In: Journal of thoracic oncology.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile27 Downloads (Pure) -
Epstein-Barr virus status drives morphological and molecular intra-tumour heterogeneity in gastric cancer: insights from a case report and literature review
Gullo, I., Sacramento, M. L., Morais, R., Kim, Y., Eijk, P. P., Rocha, A. M., Baptista, D., Santos-Antunes, J., Ylstra, B. & Carneiro, F. T., 2025, (E-pub ahead of print) In: Virchows Archiv.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile31 Downloads (Pure) -
Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling
Vallentgoed, W. R., Hoogstrate, Y., van Garderen, K. A., van Hijfte, L., van Dijk, E., Kouwenhoven, M. C. M., Niers, J. M., Draaisma, K., Martin, I., de Leng, W. W. J., Tesileanu, C. M. S., de Heer, I., Diepeveen, M., Lavrova, A., Eijk, P. P., Bühler, M., Wick, W., Clement, P. M., Sanson, M. & Franceschi, E. & 14 others, , Oct 2025, In: Nature Cancer. 6, 10, p. 1693-1713 21 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile29 Downloads (Pure)