Personal profile
Research interests
My research comprises 3 lines of investigation:
1. to identify with system biology approaches critical factors affecting the development of insulin resistance (IR) and type 2 diabetes (T2D) in obese individuals. A vast amount of data has recently become available from genomic and metabolomic studies, but the challenge is to integrate these data into a comprehensive model of obesity-induced changes. Our approaches include causal network analysis, modelling of whole body glucose metabolism and controlled manipulation of the expression of candidate genes in human cell lines. Particular attention is given to the importance of changes in glycosphingolipid metabolism (in collaboration with Prof. J.M. Aerts, Dept of Med Biochemistry, AMC).
2. to study the differentiation process of adipocytes in order to understand the derangements caused by metabolic overloading. This research is carried out in ex vivo model systems and in samples obtained from human studies (in collaboration with the Metabolic Unit at the AMC, Dr. M.J. Serlie).
My research is supported by the AMC Innovation Impulse.
1. to identify with system biology approaches critical factors affecting the development of insulin resistance (IR) and type 2 diabetes (T2D) in obese individuals. A vast amount of data has recently become available from genomic and metabolomic studies, but the challenge is to integrate these data into a comprehensive model of obesity-induced changes. Our approaches include causal network analysis, modelling of whole body glucose metabolism and controlled manipulation of the expression of candidate genes in human cell lines. Particular attention is given to the importance of changes in glycosphingolipid metabolism (in collaboration with Prof. J.M. Aerts, Dept of Med Biochemistry, AMC).
2. to study the differentiation process of adipocytes in order to understand the derangements caused by metabolic overloading. This research is carried out in ex vivo model systems and in samples obtained from human studies (in collaboration with the Metabolic Unit at the AMC, Dr. M.J. Serlie).
My research is supported by the AMC Innovation Impulse.
Specialisation
Medical Biochemistry
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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ATP8B1 Deficiency Causes Phosphodiesterase 4-Mediated Glucagon Resistance and Impaired Gluconeogenesis in Mouse and Human Liver
Chang, J.-C., Panhuis, W. I. H., Hsu, S.-H., Duijst, S., Ho-Mok, K. S., van der Heiden, J. F., Ying, Z., Erdmann, J. I., Vogel, G. F., Junge, N., Hartleben, B., Koelink, P. J., van Dijk, S. G., Peng, W. C., Verhoeven, A. J., Oude Elferink, R. P. J., Chen, H.-L., van de Graaf, S. F. J. & Paulusma, C. C., 1 Sept 2025, In: Liver international. 45, 9, e70306.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Downloads (Pure) -
The role of bile salts in itch receptor activation
Wolters, F., Tolenaars, D., van Weeghel, M., de Waart, D., van de Graaf, S. F. J., Paulusma, C. C., Verhoeven, A., Beuers, U. & Oude Elferink, R., 1 Nov 2025, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1871, 8, 167972.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Downloads (Pure) -
Carboxylesterase 1 directs the metabolic profile of dendritic cells to a reduced inflammatory phenotype
Elfiky, A. M. I., Canñizares, J. L. P., Li, J., Li Yim, A. Y. F., Verhoeven, A. J., Ghiboub, M. & de Jonge, W. J., 4 Nov 2024, In: Journal of leukocyte biology. 116, 5, p. 1094-1108 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile88 Downloads (Pure) -
Correction to: The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD+ redox state (Apoptosis, (2021), 26, 1-2, (38-51), 10.1007/s10495-020-01648-8)
Go, S., Kramer, T. T., Verhoeven, A. J., Elferink, R. P. J. O. & Chang, J.-C., Dec 2024, In: Apoptosis. 29, 11-12, p. 1858-1859 2 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open AccessFile22 Downloads (Pure) -
Opposite regulation of glycogen metabolism by cAMP produced in the cytosol and at the plasma membrane
Bizerra, P. F. V., Gilglioni, E. H., Li, H. L., Go, S., Oude Elferink, R. P. J., Verhoeven, A. J. & Chang, J.-C., 1 Jan 2024, In: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1871, 1, 119585.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile66 Downloads (Pure)