Research output per year
Research output per year
Personal profile
Specialisation
Pediatric Nephrology
Research interests
My research interests involve idiopathic nephrotic syndrome in children, unraveling the pathogenesis (Immunomics), prevention of first relapse with combination therapy of prednisolone and levamisole (multicenter, international RCT), pharmacokinetics and pharmacodynamics (PKPD) of prednisolone and levamisole (LC-MS technique) and the applicability of saliva, HRQoL and parental distress (KLIK website) of children with first episode INS. With Heidelberg Certain working group we investigate the recurrence of nephrotic syndrome after kidney transplantation in children in Europe: risk factors, treatment and outcome. The immunosuppressive treatment of children after kidney transplantation is guided by plasma concentration levels. Overimmunosuppression leads to increased risk of infections and PTLD and underimmunosuppression to rejection and graftfailure. The TTV-TX projects investigates if the level of Torque Teno Virus (with PCR) in blood can be of additional benefit in immunosuppressive dosing. We are also analyzing what happens with the donor anellome in the recipient (Next generation sequencing).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Functional and Immunological studies in children with chronic renal failure: the effects of uremia and dialysis treatment., University of Amsterdam
1 Nov 1995 → 1 Apr 2000
Award Date: 4 Oct 2001
Keywords
- QR355 Virology
- RJ101 Child Health. Child health services
- QR180 Immunology
- RM Therapeutics. Pharmacology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Bridging pediatric and adult IgAN: challenges in applying proteinuria-driven recommendations in the new IPNA guidelines
Cambier, A., Dossier, C., Lapeyraque, A.-L., Phan, V. R., Laroche, C., Abukasm, K., Benoit, G., Roy, J.-P., Hogan, J., Boyer, O., Monteiro, R., Licht, C., Goodyer, P., Downie, M., Bouts, A., Boutaba, M., Ulinski, T., Troyanov, S. & Haas, M., Jul 2025, In: Pediatric Nephrology. 40, 7, p. 2107-2111 5 p.Research output: Contribution to journal › Editorial › Academic › peer-review
Open AccessFile5 Downloads (Pure) -
Diagnosis, management and treatment of the Alport syndrome - 2024 guideline on behalf of ERKNet, ERA and ESPN
Torra, R., Lipska-Zietkiewicz, B., Acke, F., Antignac, C., Becker, J. U., Cornec-le Gall, E., van Eerde, A. M., Feltgen, N., Ferrari, R., Gale, D. P., Gear, S., Gross, O., Haeberle, S., Heidet, L., Lennon, R., Massella, L., Pfau, K., Pizarro, M. D. P. V., Topaloglu, R. & Wlodkowski, T. & 2 others, , 1 Jun 2025, In: Nephrology Dialysis Transplantation. 40, 6, p. 1091-1106 16 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Factors associated with statural growth in pediatric kidney transplant recipients with focus on metabolic acidosis
Prytuła, A., Reynders, D., Goetghebeur, E., Krupka, K., Bacchetta, J., Kanzelmeyer, N., Guzzo, I., Labbadia, R., Benetti, E., Shenoy, M., Sellier-Leclerc, A.-L., Oh, J., Litwin, M., Rubik, J., Awan, A., Bilge, I., Weber, L. T., Müller, D., Simon, T. & Pape, L. & 2 others, , Jun 2025, In: Pediatric Nephrology. 40, 6, p. 2059-2070 12 p., e14029.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile13 Downloads (Pure) -
Glycoproteomics analysis of complement factor H and its complement-regulatory function during Streptococcus pneumoniae-associated hemolytic uremic syndrome
Baas, L. M., Wijnsma, K. L., Zijlstra, F., van de Kar, N. C. A. J., ter Steeg, L., Bouts, A. H. M., Michels, M. A. H. M., Langereis, J. D., Lefeber, D., Wessels, H. J. C. T. & van den Heuvel, L. P., 2025, In: Frontiers in immunology. 16, 1645196.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Downloads (Pure) -
Insights from ADPedKD, ERKReg and RaDaR registries provide a multi-national perspective on the presentation of childhood autosomal dominant polycystic kidney disease in high- and middle-income countries
Gimpel, C., Fieuws, S., Hofstetter, J., Pitcher, D., Vanmeerbeek, L., Haeberle, S., Dachy, A., Massella, L., Seeman, T., Ranchin, B., Allard, L., Bacchetta, J., Bayrakci, U. S., Becherucci, F., Perez-Beltran, V., Besouw, M., Bialkevich, H., Boyer, O., Canpolat, N. & Chauveau, D. & 49 others, , Jul 2025, In: Kidney international. 108, 1, p. 105-118 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure)