Projects per year
Personal profile
Research interests
My research is focused on (RNA) biology in the iPS-cell derived cardiomyocyte.
In these cells we study the allelic imbalance as explanation for differences in disease severity in inherited cardiac diseases, including both arrhythmic diseases and cardiomyopathies. We try to unravel the mechanisms underlying allelic imbalance ranging from imprinting to effects on miRNA or enhancer functions. On top of that we use allele-specific shRNAs to induce allelic imbalance in these inherited cardiac diseases as possible new therapeutics.
Furthermore, we study the effect of loss of circular RNAs, a newly identified type of non-coding RNA, on the cardiomyocyte and try to unravel how these specific circular RNAs affect the cardiomyocytes.
Specialisation
Molecular Cardiology, non-coding RNA, iPS-cells
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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NHS Dekker Tijsen (Stiggelbout)): Dekker Senior Scientist 2022 - Prime-editing to cure genetic cardiomyopathies - dr. W. Stiggelbout-programma
Pinto, Y. (Principal investigator) & Tijsen, A. (Project Leader)
01/01/2023 → 31/12/2027
Project: Research
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NHS Dekker Tijsen: Dekker Senior Scientist 2022 - Prime-editing to cure genetic cardiomyopathies
Pinto, Y. (Principal investigator) & Tijsen, A. (Project Leader)
01/01/2023 → 31/12/2026
Project: Research
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TKI call 2022 - TRACER: RNA therapies to treat cardiomyopathies caused by mutations in RBM20
Pinto, Y. (Principal investigator) & Tijsen, A. (Project Member)
Stichting Life Sciences Health -TKI
01/11/2022 → 01/11/2025
Project: Research
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Off Road Tijsen: 'Prime-editing in human induced pluripotent stem cells to cure the genetic basis of laminopathies’
Pinto, Y. (Principal investigator) & Tijsen, A. (Project Leader)
01/01/2023 → 30/04/2024
Project: Research
Research output
- 8 Article
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Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids
Li, J., Wiesinger, A., Fokkert, L., Bakker, P., de Vries, D. K., Tijsen, A. J., Pinto, Y. M., Verkerk, A. O., Christoffels, V. M., Boink, G. J. J. & Devalla, H. D., 7 Nov 2024, In: Cell stem cell. 31, 11, p. 1667-1684.e6Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
MicroRNAs in extracellular vesicles released from epicardial adipose tissue promote arrhythmogenic conduction slowing
Ernault, A. C., de Winter, R., Fabrizi, B., Bracht, J. W. P., Hau, C., van Amersfoorth, S. C. M., Meulendijks, E. R., Tijsen, A. J., Cócera Ortega, L., van der Made, I., Gasecka, A., Driessen, A. H., Nieuwland, R., Boukens, B. J., van der Pol, E., de Groot, J. R. & Coronel, R., 2023, (Accepted/In press) In: Heart rhythm O2.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Quaking regulates circular RNA production in cardiomyocytes
Montanes-Agudo, P., van der Made, I., Aufiero, S., Tijsen, A. J., Pinto, Y. M. & Creemers, E. E., 1 Jul 2023, In: Journal of cell science. 136, 13, jcs261120.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Characterization of the mechanism by which a nonsense variant in RYR2 leads to disordered calcium handling
Hopton, C., Tijsen, A. J., Maizels, L., Arbel, G., Gepstein, A., Bates, N., Brown, B., Huber, I., Kimber, S. J., Newman, W. G., Venetucci, L. & Gepstein, L., 1 Apr 2022, In: Physiological reports. 10, 8, e15265.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Long non-coding RNA MEG8 induces endothelial barrier through regulation of microRNA-370 and -494 processing
Kremer, V., Stanicek, L., van Ingen, E., Bink, D. I., Hilderink, S., Tijsen, A. J., Wittig, I., Mägdefessel, L., Nossent, A. Y. & Boon, R. A., 15 Jun 2022, In: Journal of cell science. 135, 12Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Datasets
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Additional file 6 of circRNAprofiler: an R-based computational framework for the downstream analysis of circular RNAs
Aufiero, S. (Creator), Reckman, Y. J. (Contributor), Tijsen, A. J. (Creator), Pinto, Y. M. (Creator) & Creemers, E. E. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12218798.v1, https://springernature.figshare.com/articles/Additional_file_6_of_circRNAprofiler_an_R-based_computational_framework_for_the_downstream_analysis_of_circular_RNAs/12218798/1
Dataset
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Additional file 5 of circRNAprofiler: an R-based computational framework for the downstream analysis of circular RNAs
Aufiero, S. (Creator), Reckman, Y. J. (Contributor), Tijsen, A. J. (Creator), Pinto, Y. M. (Creator) & Creemers, E. E. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12218795, https://springernature.figshare.com/articles/Additional_file_5_of_circRNAprofiler_an_R-based_computational_framework_for_the_downstream_analysis_of_circular_RNAs/12218795
Dataset
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Additional file 3 of circRNAprofiler: an R-based computational framework for the downstream analysis of circular RNAs
Aufiero, S. (Creator), Reckman, Y. J. (Contributor), Tijsen, A. J. (Creator), Pinto, Y. M. (Creator) & Creemers, E. E. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12218783.v1, https://springernature.figshare.com/articles/Additional_file_3_of_circRNAprofiler_an_R-based_computational_framework_for_the_downstream_analysis_of_circular_RNAs/12218783/1
Dataset
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Additional file 2 of circRNAprofiler: an R-based computational framework for the downstream analysis of circular RNAs
Aufiero, S. (Creator), Reckman, Y. J. (Contributor), Tijsen, A. J. (Creator), Pinto, Y. M. (Creator) & Creemers, E. E. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12218780.v1, https://springernature.figshare.com/articles/Additional_file_2_of_circRNAprofiler_an_R-based_computational_framework_for_the_downstream_analysis_of_circular_RNAs/12218780/1
Dataset
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Additional file 3 of circRNAprofiler: an R-based computational framework for the downstream analysis of circular RNAs
Aufiero, S. (Creator), Reckman, Y. J. (Contributor), Tijsen, A. J. (Creator), Pinto, Y. M. (Creator) & Creemers, E. E. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12218783, https://springernature.figshare.com/articles/Additional_file_3_of_circRNAprofiler_an_R-based_computational_framework_for_the_downstream_analysis_of_circular_RNAs/12218783
Dataset