Research output per year
Research output per year
Personal profile
Specialisation
neuroscience, cell biology, axon initial segment, membrane trafficking, plasticity
Research interests
My lab is interested in understanding the molecular mechanisms allowing neurons to adapt their activity level in order to ensure network homeostasis. We focus our research on the adaptations occuring at the level of the axon intial segment.
To unravel the molecular mechanisms controlling the axon intial segment organization and re-roganization during plasticity, we combine genome engineering with live- and super resolution imaging in cultured rodent and human iPSC-derived neurons. This allows us to image the nanoscale organization of the building blocks of the axon initial segment and their dynamics during plasticity.
Fingerprint
Dive into the research topics where Amélie Fréal is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Sodium channel endocytosis drives axon initial segment plasticity
Fréal, A., Jamann, N., Ten Bos, J., Jansen, J., Petersen, N., Ligthart, T., Hoogenraad, C. C. & Kole, M. H. P., 15 Sept 2023, In: Science advances. 9, 37, p. eadf3885Research output: Contribution to journal › Article › Academic › peer-review
-
Feedback-Driven Assembly of the Axon Initial Segment
Fréal, A., Rai, D., Tas, R. P., Pan, X., Katrukha, E. A., van de Willige, D., Stucchi, R., Aher, A., Yang, C., Altelaar, A. F. M., Vocking, K., Post, J. A., Harterink, M., Kapitein, L. C., Akhmanova, A. & Hoogenraad, C. C., 23 Oct 2019, In: Neuron. 104, 2, p. 305-321.e8Research output: Contribution to journal › Article › Academic › peer-review
-
Cooperative Interactions between 480 kDa Ankyrin-G and EB Proteins Assemble the Axon Initial Segment
Fréal, A., Fassier, C., Le Bras, B., Bullier, E., De Gois, S., Hazan, J., Hoogenraad, C. C. & Couraud, F., 20 Apr 2016, In: Journal of neuroscience. 36, 16, p. 4421-33 13 p.Research output: Contribution to journal › Article › Academic › peer-review
-
The dynamic axon initial segment: From neuronal polarity to network homeostasis
Fréal, A. & Hoogenraad, C. C., 5 Mar 2025, In: Neuron. 113, 5, p. 649-669 21 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access -
The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling
Dorrego-Rivas, A., Ezan, J., Moreau, M. M., Poirault-Chassac, S., Aubailly, N., De Neve, J., Blanchard, C., Castets, F., Fréal, A., Battefeld, A., Sans, N. & Montcouquiol, M., 9 Sept 2022, In: Science advances. 8, 36, p. eabo6333Research output: Contribution to journal › Article › Academic › peer-review