Projects per year
Personal profile
Specialisation
clinical neurophysiology, dementia, Alzheimer's disease, electro- / magnetoencephalography, functional connectivity
Research interests
My research focuses on neurophysiological changes in Alzheimer's disease patients.
On the one hand, my aim is to further unravel the origins of Alzheimer's disease by 1) investigating the role of the magnetoencephalography-based functional brain network in the spread of tau-proteins, and 2) finding proof for neuronal hyperexcitability as a key early factor in Alzheimer's disease patients in a translational mice-human project and in patients with interictal epileptiform discharges.
On the other hand, my focus is to find sensitive and robust neurophysiological biomarkers for support in diagnostic decision making, in predicting progression of the disease and in monitoring treatment outcome.
Keywords
- RZ Other systems of medicine
- QP Physiology
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Collaborations and top research areas from the last five years
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Projects
- 2 Finished
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T-Rex: Interneuron networks in Alzheimer's disease: diagnostic and therapeutic implications
Gouw, A. (Principal investigator)
01/05/2019 → 30/04/2024
Project: Research
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MANTA Highroad to AD: MANTA Highroad to Alzheimer's Disease: 'does aberramt neuronal activity guide the stereotypical spread of TAU pathology
Gouw, A. (Principal investigator)
01/11/2017 → 30/11/2023
Project: Research
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Tau protein spreads through functionally connected neurons in Alzheimer's disease: a combined MEG/PET study
Schoonhoven, D. N., Coomans, E. M., Millán, A. P., van Nifterick, A. M., Visser, D., Ossenkoppele, R., Tuncel, H., van der Flier, W. M., Golla, S. S. V., Scheltens, P., Hillebrand, A., van Berckel, B. N. M., Stam, C. J. & Gouw, A. A., 1 Oct 2023, In: Brain. 146, 10, p. 4040-4054 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Resting-state oscillations reveal disturbed excitation–inhibition ratio in Alzheimer’s disease patients
van Nifterick, A. M., Mulder, D., Duineveld, D. J., Diachenko, M., Scheltens, P., Stam, C. J., van Kesteren, R. E., Linkenkaer-Hansen, K., Hillebrand, A. & Gouw, A. A., 1 Dec 2023, In: Scientific reports. 13, 1, 7419.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure) -
Network Hyperexcitability in Early Alzheimer’s Disease: Is Functional Connectivity a Potential Biomarker?
Stam, C. J., van Nifterick, A. M., de Haan, W. & Gouw, A. A., Jul 2023, In: Brain topography. 36, 4, p. 595-612 18 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Routine magnetoencephalography in memory clinic patients: A machine learning approach
Gouw, A. A., Hillebrand, A., Schoonhoven, D. N., Demuru, M., Ris, P., Scheltens, P. & Stam, C. J., Oct 2021, In: Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 13, 1, p. e12227Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Downloads (Pure) -
EEG spectral analysis as a putative early prognostic biomarker in nondemented, amyloid positive subjects
Gouw, A. A., Alsema, A. M., Tijms, B. M., Borta, A., Scheltens, P., Stam, C. J. & van der Flier, W. M., 1 Sept 2017, In: Neurobiology of aging. 57, p. 133-142 10 p.Research output: Contribution to journal › Article › Academic › peer-review
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Dutch Society for Clinical Neurophysiology (NVKNF) (External organisation)
Gouw, A. (Member)
1 Jan 2015 → 1 Apr 2019Activity: Membership › Membership of committee › Academic