Personal profile
Research interests
Experienced group leader in virology with special expertise in the HIV/AIDS field. Scientific interests focused on the persistence of HIV-1 reservoir in infected individuals. This viral reservoir is the main obstacle to an HIV-1 cure and my group aims to characterize the reservoir on the cellular and molecular levels, working at the crossroads of virology and immunology.
Specialisation
Molecular Virology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir
van Paassen, P. M., Pasternak, A. O., Bolluyt, D. C., van Dort, K. A., van Nuenen, A. C., Maurer, I., Boeser-Nunnink, B., Buchholtz, N. V. E. J., Mahmoudi, T., Lungu, C., van Crevel, R., Rokx, C., Symons, J., Nijhuis, M., van der Veen, A. L. I. P., Vogt, L., Klouwens, M. J., Prins, J. M., Kootstra, N. A. & de Bree, G. J., 23 Jan 2026, In: eLife. 14Research output: Contribution to journal › Article › Academic › peer-review
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Inhibition of ALKBH5 demethylase of m6A pathway potentiates HIV-1 reactivation from latency
Ali, H., Wadas, J., Bendoumou, M., Chen, H.-C., Maiuri, P., Dutilleul, A., Selberg, S., Nestola, L., Lalik, K., Avettand-Fenoël, V., Necsoi, C., Marcello, A., Kankuri, E., Karelson, M., de Wit, S., Pyrc, K., Pasternak, A. O., van Lint, C. & Kula-Pacurar, A., 1 Dec 2025, In: Virology journal. 22, 1, 124.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile22 Downloads (Pure) -
Long-term effect of temporary ART initiated during primary HIV-1 infection on viral persistence
Pasternak, A. O., van Paassen, P. M., Verschoor, Y. L., Vroom, J., van Dort, K. A., Maurer, I., Grijsen, M. L., Wit, F. W., de Bree, G. J., Kootstra, N. A., Prins, J. M. & Berkhout, B., 30 Jul 2025, In: Nature communications. 16, 1, 6989.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile24 Downloads (Pure) -
No associations between HIV reservoir and inflammation in long-term virally suppressed dolutegravir-based ART-treated individuals
Fombellida-Lopez, C. L., Aguilar Ortmans, D., Moutschen, M., Pasternak, A. O. & Darcis, G., 2025, In: Frontiers in immunology. 16, 1628086.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile25 Downloads (Pure) -
Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency
Dorman, A., Bendoumou, M., Valaitienė, A., Wadas, J., Ali, H., Dutilleul, A., Maiuri, P., Nestola, L., Bociaga-Jasik, M., Mchantaf, G., Necsoi, C., de Wit, S., Avettand-Fenoël, V. R., Marcello, A., Pyrc, K., Pasternak, A. O., van Lint, C. & Kula-Pacurar, A., 1 Dec 2025, In: Nat. Commun.. 16, 1, 2078.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile45 Downloads (Pure)