Projects per year
Personal profile
Research interests
With a strong background in renal aging and diseases, I study the metabolic changes and the impact of environmental toxins in these conditions.
My recent work focuses on understanding the biological mechanisms of premature renal aging, particularly the role of senescent kidney epithelial cells. The accumulation of these cells is a critical risk factor for the progression of chronic kidney disease. I investigate NAD+ metabolism, complex lipid metabolism, and immunometabolism in senescent cells during aging and disease to discover new therapeutic strategies for healthy renal aging and to slow chronic kidney disease progression.
Additionally, I study how fine and ultrafine particles from air pollution contribute to premature renal aging from early life onwards.
My research utilizes patient-derived kidney tissue, animal models, in vitro models of senescence, senescence assays, metabolic assays, iPSCs-derived kidney organoids, exposome chambers, various omics techniques, and histology.
specialisation
kidney disease, aging, senescence, metabolism, air pollution, exposome studies, developmental programming
Related documents
External positions
visiting scientist, University of São Paulo Medical School
Keywords
- RJ101 Child Health. Child health services
- RB Pathology
- RM Therapeutics. Pharmacology
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Pollution is the motor of premature ageing of the kidney
Da Conceição Andrade, L. L. (Principal investigator), Ustra, A. T. A. T. (Staff), De Fátima Andrade, M. M. (Staff), Veras, M. M. M. M. (Staff), Sanches, T. R. C. T. R. C. (Staff), Florquin, S. (CoPI), Tammaro, A. (CoPI) & Rodrigues, C. E. C. E. (Staff)
01/07/2020 → 30/06/2025
Project: Research
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The role of fine particulate matter in inducing toxic responses: from oxidative potential to kidney disease
De Fátima Andrade, M. M. (Principal investigator), Wikuats, C. F. H. C. F. H. (CoPI) & Tammaro, A. (CoPI)
Fundação de Amparo à Pesquisa do Estado de São Paulo
01/03/2023 → 29/02/2024
Project: Research
Research output
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The Purinoreceptor P2X7 in Extracellular ATP-Mediated Inflammation through the Spectrum of Kidney Diseases and Kidney Transplantation
Téllez Garcia, J. M., Steenvoorden, T., Bemelman, F., Hilhorst, M., Tammaro, A. & Vogt, L., 2025, (E-pub ahead of print) In: Clinical journal of the American Society of Nephrology.Research output: Contribution to journal › Review article › Academic › peer-review
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A conserved complex lipid signature marks human muscle aging and responds to short-term exercise
Janssens, G. E., Molenaars, M., Herzog, K., Grevendonk, L., Remie, C. M. E., Vervaart, M. A. T., Elfrink, H. L., Wever, E. J. M., Schomakers, B. V., Denis, S. W., Waterham, H. R., Pras-Raves, M. L., van Weeghel, M., van Kampen, A. H. C., Tammaro, A., Butter, L. M., van der Rijt, S., Florquin, S., Jongejan, A. & Moerland, P. D. & 4 others, , May 2024, In: Nature Aging. 4, 5, p. 681-693 13 p.Research output: Contribution to journal › Article › Academic › peer-review
7 Citations (Scopus) -
Air pollution aggravates renal ischaemia-reperfusion-induced acute kidney injury
Sanches, T. R., Parra, A. C., Sun, P., Graner, M. P., Itto, L. Y. U., Butter, L. M., Claessen, N., Roelofs, J. J. T. H., Florquin, S., Veras, M. M., Andrade, M. D. F., Saldiva, P. H. N., Kers, J., Andrade, L. & Tammaro, A., Aug 2024, In: Journal of pathology. 263, 4-5, p. 496-507 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus) -
Correction to: Obesity aggravates acute kidney injury resulting from ischemia and reperfusion in mice (Scientific Reports, (2024), 14, 1, (9820), 10.1038/s41598-024-60365-3)
da Silva, I. O., de Menezes, N. K., Jacobina, H. D., Parra, A. C., Souza, F. L., Castro, L. C., Roelofs, J. J. T. H., Tammaro, A., Gomes, S. A., Sanches, T. R. & Andrade, L., Dec 2024, In: Scientific reports. 14, 1, 11140.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open Access -
HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice
Hu, M., Tammaro, A., Daniels, E. G., ‘t Hart, K. C., Reid, K., Juni, R. P., Butter, L. M., Jongejan, A., Roelofs, J. J. T. H., Aronica, E., Boon, R. A., Houtkooper, R. H. & Janssens, G. E., 1 Jan 2024, In: iScience. 27, 1, 108681.Research output: Contribution to journal › Article › Academic › peer-review
Open Access6 Citations (Scopus)
Prizes
Press/Media
Impacts
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