Personal profile
Specialisation
Molecular biology, Regulation of gene expression, RNA Polymerases, transfer RNAs, Functional screening
Research interests
Our interests revolve around understanding how genes transcribed by RNA Polymerase III are (mis)regulated in cancer cells, particularly tRNA genes in glioblastoma. Our goal is to understand how differential regulation of these genes promotes proliferation and/or oppose cell differentiation and how to interfere with these processes to impair cancer cell survival or proliferation. We combine fundamental research in cell and molecular biology coupled with advanced screening technologies to uncover the functions of these small non-coding genes with the aim to translate this knowledge into future clinical applications.
Related documents
Education/Academic qualification
PhD, University of Geneva, Geneva, Switzerland
2007 → 2012
Award Date: 30 Jul 2012
External positions
Visiting Fellow, AIMMS, Amsterdam Institute for Molecules Medicines and Systems (AIMMS)
1 Feb 2021 → 31 Jan 2024
Visiting Fellow, Organic Chemistry, Vrije Universiteit Amsterdam
1 Feb 2021 → 31 Jan 2024
Research Associate, Vrije Universiteit Amsterdam
1 Aug 2019 → 31 Jan 2021
Postdoctoral Fellow/Research Associate, Rockefeller University
1 Mar 2014 → 31 Jul 2019
Postdoctoral Associate, University of Geneva, Geneva, Switzerland
Jul 2012 → Mar 2014
Visiting Fellow, Laboratory of Biochemistry and Molecular Biology, Rockefeller University
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Gene-Specific Control of tRNA Expression by RNA Polymerase II
Gerber, A., Ito, K., Chu, C. S. & Roeder, R. G., 21 May 2020, In: Molecular cell. 78, 4, p. 765-778 14 p.Research output: Contribution to journal › Article › Academic › peer-review
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The CTD Is Not Essential for the Post-Initiation Control of RNA Polymerase II Activity
Gerber, A. & Roeder, R. G., 4 Sept 2020, In: Journal of molecular biology. 432, 19, p. 5489-5498 10 p.Research output: Contribution to journal › Article › Academic › peer-review
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Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity
Gerber, A., Esnault, C., Aubert, G., Treisman, R., Pralong, F. & Schibler, U., 31 Jan 2013, In: Cell. 152, 3, p. 492-503 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles
Sinturel, F., Gerber, A., Mauvoisin, D., Wang, J., Gatfield, D., Stubblefield, J. J., Green, C. B., Gachon, F. & Schibler, U., 4 May 2017, In: Cell. 169, 4, p. 651-663.e14Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Functions of paralogous RNA polymerase III subunits polr3g and polr3gl in mouse development
Wang, X., Gerber, A., Chen, W. Y. & Roeder, R. G., 7 Jul 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 27, p. 15702-15711 10 p.Research output: Contribution to journal › Article › Academic › peer-review
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