Personal profile
Research interests
Translational projects in non-alcoholic fatty liver disease, supported by Amsterdam UMC Fellowship 2018:
- innovation of multidisciplinary care
- ANCHOR: Amsterdam NAFLD-NASH cohort study @ AMC & VUmc
- LITMUS EU biobank (AMC: Dutch lead center)
- NILE project: prevalence and genetics of NAFLD in the multiethnic Helius cohort
- CRISTINA exercise intervention study in NAFLD
- lipid and liver pathways in rare metabolic diseases, with a focus on defects in lipophagy
- BARNARD: probiotics in mouse models of NAFLD
Specialisation
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Collaborations and top research areas from the last five years
Research output
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Weight Change is Associated With Metabolic Liver Health in a General Population Extending Beyond Weight Loss Targets of International Guidelines
van Kleef, L. A., Savas, M., Michel, M., Caussy, C., Pustjens, J., Holleboom, A. G., van Rossum, E. F. C., Janssen, H. L. A., Schattenberg, J. R. M. & Brouwer, W. P., 1 Jan 2026, In: Gastro Hep Advances. 5, 2, 100831.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile31 Downloads (Pure) -
ALT Is an Effective Screening Tool for Advanced Metabolic Dysfunction-Associated Steatotic Liver Disease in Children With Obesity and Overweight
Stroes, A.-S. R., Draijer, L., Chegary, M., Kreier, F., van Os, E., Goede, J., Boonstra, V., Westerbeek, I., Bouma, S., Kusters, M., Roelants, R., Beuers, U., Holleboom, A. G., Benninga, M. A. & Koot, B. G. P., 2025, (E-pub ahead of print) In: Clinical gastroenterology and hepatology.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile39 Downloads (Pure) -
Beta-Klotho Protein Expression in Healthy Human Tissues and Liver Biopsies From Patients With MASLD or MASH
Aaldijk, A. S., Struik, D., Driessen, S., Verzijl, C. R. C., Verheij, J., Nieuwdorp, M., Eilers, R., Wolters, J. C., Holleboom, A. G. & Jonker, J. W., 1 Jan 2025, In: Gastro Hep Advances. 4, 10, 100745.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile35 Downloads (Pure) -
COMPARISON OF DIAGNOSTIC ACCURACY AND UTILITY OF NON-INVASIVE TESTS FOR CLINICALLY SIGNIFICANT LIVER DISEASE IN A GENERAL POPULATION WITH METABOLIC DYSFUNCTION
van Kleef, L. A., Pustjens, J., Schattenberg, J. R. M., Holleboom, A. G., Cabezas, M. C., Tushuizen, M. E., de Knegt, R. J., Ikram, M. A., Janssen, H. L. A., Francque, S. M. & Brouwer, W. P., 2025, (E-pub ahead of print) In: Hepatology. 10.1097/HEP.0000000000001356.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile82 Downloads (Pure) -
Deep phenotyping of patients with MASLD upon high-intensity interval training
Houttu, V., Boulund, U., Troelstra, M., Csader, S., Stols-Gonçalves, D., Mak, A. L., Dijk, A.-M. V., Bouts, J., Winkelmeijer, M., Verdoes, X., van den Berg-Faay, S., Lek, D., Ronteltap, T., de Haan, F., Jorstad, H., Männistö, V., Savonen, K., Pentikäinen, H., Hanhineva, K. & Babu, A. F. & 9 others, , 1 Mar 2025, In: JHEP Reports. 7, 3, 101289.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile33 Downloads (Pure)